{"id":1894,"date":"2020-04-29T16:26:20","date_gmt":"2020-04-29T16:26:20","guid":{"rendered":"https:\/\/theduff.co.uk\/?p=1894"},"modified":"2021-01-21T12:11:33","modified_gmt":"2021-01-21T12:11:33","slug":"why-does-ivf-fail","status":"publish","type":"post","link":"https:\/\/theduff.co.uk\/why-does-ivf-fail\/","title":{"rendered":"<strong>Why does IVF fail?<\/strong> A list of possible reasons"},"content":{"rendered":"\n<p><strong>WHEN YOU'VE BEEN DEALT THE HORRIBLE BLOW THAT YOUR IVF FAILED<\/strong>, it's so easy to fall into the trap of constantly thinking, &#8220;What did I do wrong?&#8221; and\/or &#8220;Where did my doctors fail me?&#8221; <\/p>\n\n\n\n<p>Now, if you forgot to take all your medication or you <a href=\"\/egg-quality-quantity-ovarian-reserve\/\">chain-smoked<\/a> your way through treatment, I'll admit you maaaaybe deserve some of the blame. Likewise, if your doctors mistook your multiple cysts for follicles or accidentally flushed away your petri dish of embryos, they deserve to be, well, struck off. <\/p>\n\n\n\n<p>But IVF failure is SO often just a case of bad luck \u2013 just as IVF success is SO often just a case of good luck. I want to emphasise this point so strongly, <strong>so I'll put it in bold: much of the time, IVF succeeds or fails because of nothing more than good or bad luck. <\/strong><\/p>\n\n\n\n<p>Yet it isn't <em>always <\/em>down to luck. Here's what you need to know&#8230; <\/p>\n\n\n<style>.elementor-572 .elementor-element.elementor-element-189190b1{padding:0% 36% 8% 22%;}.elementor-572 .elementor-element.elementor-element-6b407887 > .elementor-element-populated{margin:0% 3.2% 0% 14%;--e-column-margin-right:3.2%;--e-column-margin-left:14%;}.elementor-572 .elementor-element.elementor-element-65191d58{--box-background-color:#FCFAEE;--box-border-color:#007595;--box-border-width:0px;--box-border-radius:0px;--box-padding:24px;--box-min-height:48vh;--header-color:#F16653;--toggle-button-color:#333333;--item-text-color:#007595;--item-text-decoration:underline;--item-text-hover-decoration:underline;--marker-color:#007595;}.elementor-572 .elementor-element.elementor-element-65191d58 .elementor-toc__header, .elementor-572 .elementor-element.elementor-element-65191d58 .elementor-toc__header-title{font-size:20px;}.elementor-572 .elementor-element.elementor-element-65191d58 .elementor-toc__list-item{font-size:20px;}.elementor-572 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#333333;\n}\n\n.elementor-toc__list-wrapper {\n    margin: 0em 2em 2em 0em;\n}\n\n.elementor-toc__list-items--collapsible li:not(:last-of-type) {\n    margin: 1.5em 0em;\n    padding-bottom: 1.5em;\n    border-bottom: 0.5px solid #007595;\n}\n\n\/* --- For Mobile --- *\/\n@media only screen and (max-width: 400px) {\n    .elementor-toc__list-wrapper {\n    margin: -1em 0em 0em 0em;\n}\n\n.elementor-toc__list-items--collapsible li:not(:last-of-type) {\n    margin: 1.2em 0em;\n    padding-bottom: 1.2em;\n    border-bottom: 0.5px solid #007595;\n}\n}\/* End custom CSS *\/<\/style>\t\t<div data-elementor-type=\"section\" data-elementor-id=\"572\" class=\"elementor elementor-572\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-189190b1 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"189190b1\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6b407887\" data-id=\"6b407887\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-65191d58 elementor-toc--minimized-on-none elementor-widget elementor-widget-table-of-contents\" data-id=\"65191d58\" data-element_type=\"widget\" data-settings=\"{&quot;exclude_headings_by_selector&quot;:[],&quot;collapse_subitems&quot;:&quot;yes&quot;,&quot;min_height&quot;:{&quot;unit&quot;:&quot;vh&quot;,&quot;size&quot;:48,&quot;sizes&quot;:[]},&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;minimized_on&quot;:&quot;none&quot;,&quot;marker_view&quot;:&quot;bullets&quot;,&quot;icon&quot;:{&quot;value&quot;:&quot;fas fa-circle&quot;,&quot;library&quot;:&quot;fa-solid&quot;},&quot;minimize_box&quot;:&quot;yes&quot;,&quot;hierarchical_view&quot;:&quot;yes&quot;,&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toc__header\">\n\t\t\t<h4 class=\"elementor-toc__header-title\">\n\t\t\t\tContents\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--expand\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__65191d58\" aria-expanded=\"true\" aria-label=\"Open table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-down\"><\/i><\/div>\n\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--collapse\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__65191d58\" aria-expanded=\"true\" aria-label=\"Close table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-up\"><\/i><\/div>\n\t\t\t\t\t<\/div>\n\t\t<div id=\"elementor-toc__65191d58\" class=\"elementor-toc__body elementor-toc__list-items--collapsible\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\n\n\n<h2 class=\"wp-block-heading\"><strong>Why does IVF fail before egg retrieval?<\/strong><\/h2>\n\n\n\n<p>When IVF fails before egg collection, there's often a reason that your doctors will be able to explain. The main ones are: <\/p>\n\n\n\n<ul><li>They might have to halt the process because you're growing too many follicles (which puts you at risk of <a href=\"\/ovarian-hyperstimulation-syndrome-ohss-ivf\/\">OHSS<\/a>). <\/li><li>You might not be responding well enough to the drugs, so it's often better to stop the process and start again with a different treatment protocol. <\/li><\/ul>\n\n\n\n<p>I read lots of comments from people blaming their doctors for these two situations: <\/p>\n\n\n\n<ul><li>&#8220;They should have known from my <a href=\"https:\/\/theduff.co.uk\/ivf-process-start-to-finish\/\">baseline tests<\/a> that I was bound to <a href=\"https:\/\/theduff.co.uk\/ovarian-hyperstimulation-syndrome-ohss-ivf\/\">over-respond<\/a>!&#8221; <\/li><li>&#8220;I'm <a href=\"https:\/\/theduff.co.uk\/egg-quality-quantity-ovarian-reserve\/\">so old<\/a> that the candles now cost more than the cake&#8230; <em>any<\/em> idiot could have told them I'd need a shedload of stimulation drugs!&#8221;<\/li><\/ul>\n\n\n\n<p>To be honest, there can be a bit of truth in these kinds of complaints: I know this to be the case from my own experience. <\/p>\n\n\n\n<p>It's not that doctors are being stupid, of course, but occasionally they don't feel they have the time to read through your notes during your appointment scan. Instead, they'll shove the dildocam up you, scribble some things on a sheet of paper that gets haphazardly shoved inside a ring binder, then adjust your medication without double-checking your medical history. Then they'll say goodbye with one eye on the clock, and you'll walk out dutifully, with a million unanswered questions and fears in your head. <\/p>\n\n\n\n<p>If you had this experience last time, stay where you are next time \u2013 and get answers to those questions. After all, you've worn an easy-access skirt and baggy knickers to save time on the &#8220;undressing&#8221; part (while the patient before you was in lace-up boots and skinny jeans), so you can reclaim some of those minutes on your questions. <\/p>\n\n\n\n<p>Make your doctor explain things you don't understand. Ask about your treatment (here's a helpful <a href=\"https:\/\/the-duff.ck.page\/24e6138b8f\">list of questions to ask your doctor at every stage of treatment<\/a>). Get them to go through your notes if you're convinced they're taking the wrong course of action. Stand your ground and make sure that <em>if <\/em>your treatment gets cancelled before egg retrieval, you'll <em>know<\/em> it's just a case of bad luck and there's no one to blame. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Why does IVF fail before embryo transfer (but after egg retrieval)? <\/strong><\/h2>\n\n\n\n<p>If your egg retrieval went well and your doctors managed to collect at least a few eggs, it's a great first step. Unfortunately, those eggs still have a bit of a perilous journey ahead of them&#8230; <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Reason 1: the egg(s) didn't fertilise<\/strong><\/h3>\n\n\n\n<p>When the eggs and sperm are put together in a petri dish, the obvious hope is that the'll fertilise. But <a href=\"https:\/\/youtu.be\/RbfiXSO6dy4\">just like pandas who <em>really <\/em>need to mate to ensure the survival of their species<\/a>, male and female sex cells sometimes don't know what's good for them. And they fail to fuse. <\/p>\n\n\n\n<p>Often, this is simply down to bad luck. It's a thoroughly shitty situation to experience after all the IVF rigmarole that came before it, but there's no one to blame and nothing to change next time. Remember that it often takes perfectly fertile couples a while to get pregnant too: most sources state that somewhere <a href=\"https:\/\/www.babycentre.co.uk\/a1813\/how-long-will-it-take-to-get-pregnant\">between<\/a> <a href=\"https:\/\/www.webmd.com\/baby\/qa\/what-are-the-odds-of-getting-pregnant\">15% and 30%<\/a> of healthy, young couples will conceive within the first month of trying. <\/p>\n\n\n\n<p>But sometimes, there's more to it than &#8220;bad luck&#8221;. For example: <\/p>\n\n\n\n<ul><li><a href=\"\/egg-quality-quantity-ovarian-reserve\/\">The older you are<\/a>, the more &#8220;poor quality&#8221; eggs you'll have in your batch. Poor-quality eggs struggle to fertilise (among other drawbacks), so that could be why there were metaphorical crickets in the petri dish. <br><br>There are a few things you can try to improve your egg quality; <a href=\"\/egg-quality-quantity-ovarian-reserve\/\">read about them here<\/a>. <\/li><li>The issue of poor-quality eggs isn't confined to older women: some younger women suffer from a disproportionate number of them too. While age is the most important determinant, egg quality is also affected by smoking, drug use, endometriosis, ovarian cysts, obesity, some immunological disorders, radiation therapy and chemotherapy. <\/li><li>Sorry to bring up age again, but there's another reason it could be a factor. <a style=\"font-size: inherit; background-color: initial;\" href=\"\/egg-quality-quantity-ovarian-reserve\/\">Age affects the <em>number<\/em> of eggs you have<\/a><span style=\"font-size: inherit; background-color: initial;\"> \u2013 not just the quality of those eggs. That means you may not produce as many eggs as a younger person would produce<\/span>.<br><br>That's a problem because fertilisation is largely a numbers game: even good-quality eggs aren't guaranteed to fertilise. If only two eggs are retrieved, you'll have a smaller chance of fertilisation than if 20 eggs were retrieved. <br><br>To give you a real-life example, my egg collection resulted in FORTY-ONE eggs. (<a href=\"\/ovarian-hyperstimulation-syndrome-ohss-ivf\/\">Overstimulation<\/a> will do that to you, and it's not advisable.) Of those 41 eggs, about 30 fertilised. Of those 30-ish fertilised eggs, 18 made it to &#8220;<a href=\"\/day-3-vs-day-5-embryos\/\">Day 5\/Day 6<\/a>&#8221; embryos (&#8220;<a href=\"\/zygote-embryo-blastocyst-foetus-ivf\/\">blastocyst<\/a>&#8221; stage), ready to be frozen. <br><br>To end up with 18 blastocysts was a fantastic result, but it was only about 44% of all the eggs I started with. That's why the number of eggs you have is related to fertilisation success. <\/li><li>It's also possible that your partner's sperm is the issue. (<a href=\"\/sperm-collection-ivf\/\">More info here<\/a><span style=\"font-size: inherit; background-color: initial;\">.) He should have already been checked out before IVF, but you can always ask for another test to make sure. <\/span><br><br>If it turns out that sperm is causing fertilisation problems, your doctors may recommend ICSI next time (if IVF didn't work this time for sperm-related reasons). <\/li><li><strong>Did IVF fail because you didn't eat enough pomegranate or pineapple?<\/strong> Would you have been more successful if you'd bulk-bought CoQ10 or DHEA (likely against your doctor's wishes)? Should you have had more full-fat dairy? Perhaps Brazil nuts? Cut down on coffee? The answer is likely a big fat <a href=\"\/ivf-food-pomegranate-pineapple-chips-coq10-dhea-acupuncture\/\">NO<\/a> \u2013 so stop beating yourself up about it. <\/li><\/ul>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/theduff.co.uk\/wp-content\/uploads\/2020\/02\/Group-1285@2x.png\" alt=\"\" class=\"wp-image-492\" width=\"229\" height=\"105\" srcset=\"https:\/\/theduff.co.uk\/wp-content\/uploads\/2020\/02\/Group-1285@2x.png 443w, https:\/\/theduff.co.uk\/wp-content\/uploads\/2020\/02\/Group-1285@2x-300x137.png 300w\" sizes=\"(max-width: 229px) 100vw, 229px\" \/><\/figure><\/div>\n\n\n\n<p><\/p>\n\n\n<style>.elementor-291 .elementor-element.elementor-element-4c84a175{margin-top:2%;margin-bottom:12%;padding:1% 4% 1% 4%;z-index:2;}.elementor-291 .elementor-element.elementor-element-554afbfb > .elementor-element-populated{margin:0% 5% 0% 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elementor-element-7c412ba7\" data-id=\"7c412ba7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-144e6175 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"144e6175\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\" id=\"fdg\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">FREE DOWNLOAD<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ed2b9df elementor-widget elementor-widget-heading\" data-id=\"1ed2b9df\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Questions to ask your doctor at every stage of IVF treatment: free downloadable guide<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39ffc0a2 elementor-widget elementor-widget-text-editor\" data-id=\"39ffc0a2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>IVF isn\u2019t just overwhelming<\/strong>; it can also be a mind-boggling and sometimes terrifying experience because there\u2019s so much to learn and so many rules to follow.<\/p><p>Problem is, doctors are busy \u2013 and they often don\u2019t have the time to anticipate your concerns and provide all the information you might need.<\/p><p>This downloadable guide contains questions that will help you understand the process better, get the answers you deserve, and feel more in control 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elementor-col-20 e-form__buttons elementor-md-25 elementor-sm-100\">\n\t\t\t\t\t<button type=\"submit\" class=\"elementor-button elementor-size-lg\">\n\t\t\t\t\t\t<span >\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\" elementor-button-icon\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Get the PDF<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/button>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/form>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e68b04a elementor-widget elementor-widget-text-editor\" data-id=\"4e68b04a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>I won't send you spam. Unsubscribe at any time.<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\n\n\n<h3 class=\"wp-block-heading\"><strong>Reason 2: at least one egg fertilised successfully, but it\/they failed to develop in the laboratory<\/strong><\/h3>\n\n\n\n<p>As above, this is often just down to bad luck. Not all fertilised eggs will develop into embryos \u2013 and that's true whether they're in the &#8220;natural&#8221; surroundings of the fallopian tube or the slightly more artificial surroundings of the fertility lab. <\/p>\n\n\n\n<p><strong>There's something I want to emphasise again, so I will<\/strong>. Even when pregnancy is attempted the &#8220;old-fashioned&#8221; way by couples who have zero fertility issues, it doesn't mean pregnancy is a slam-dunk. Sperm will <em>often <\/em>fail to fertilise the egg, and successfully fertilised eggs will <em>often <\/em>fail to develop. <\/p>\n\n\n\n<p>So please do remember that before you start shouting &#8220;What the f**k have you done to my future babies, you f**king morons???&#8221; at the embryologist who's desperately trying to help. (This kind of thing happens, apparently.)<\/p>\n\n\n\n<p>Sometimes, though, &#8220;bad luck&#8221; isn't the only reason that a fertilised egg fails to develop in the petri dish:<\/p>\n\n\n\n<ul><li>Age could again be to blame. <a href=\"\/egg-quality-quantity-ovarian-reserve\/\">The older you are<\/a>, the more &#8220;poor quality&#8221; eggs you'll have in your batch. Poor-quality eggs don't just struggle to fertilise: they're also more likely to fail to develop into embryos.   <br><br>There are a few things you can try to improve your egg quality; <a href=\"\/egg-quality-quantity-ovarian-reserve\/\">read about them here<\/a>.<br><br>Note: some embryos are poor-quality but do end up<em> <\/em>surviving fertilisation and development. Those embryos are likely to fail to implant \u2013 but if they <em>do <\/em>implant, they're likely to be miscarried at some stage. <br><br>One of the most common ways in which an embryo is considered poor-quality is that it has the incorrect number of chromosomes \u2013 known as &#8220;aneuploidy&#8221;. An aneuploid embryo stands <a href=\"\/chromosomal-abnormalities-aneuploidy-ivf\/\">very little chance of survival<\/a>. <br><br>PGS (&#8220;preimplantation genetic screening&#8221;) can help to determine if any of your embryos are aneuploid, and thus avoid the heartache of transferring any of those embryos. <br><br>But PGS definitely isn't perfect, and it definitely doesn't guarantee success. It's also only available privately. <a href=\"\/pgs-testing-ivf\/\">Read more about PGS here<\/a>. <\/li><li>Of course, poor-quality embryos can result from poor-quality sperm too. (<a href=\"\/sperm-collection-ivf\/\">More info here<\/a>.) Your partner should have already been checked out before IVF, but you can always ask for another test to make sure. <br><br>If it turns out that sperm is causing fertilisation problems, your doctors may recommend ICSI next time (if IVF didn't work this time for sperm-related reasons). <\/li><li>As mentioned earlier, younger women can also suffer from a disproportionate number of poor-quality eggs. While age is the most important determinant, egg quality is also affected by smoking, drug use, endometriosis, ovarian cysts, obesity, some immunological disorders, radiation therapy and chemotherapy.<\/li><li>You or your partner might be a carrier of a different kind of chromosomal abnormality called a &#8220;structural abnormality&#8221;, which is something you can be tested for. <a href=\"\/chromosomal-abnormalities-aneuploidy-ivf\/\">Find out about structural abnormalities here<\/a>. <\/li><li>There's also the issue of &#8220;Day 3&#8221; vs &#8220;Day 5&#8221; embryos. The topic is covered in more detail <a href=\"\/day-3-vs-day-5-embryos\/\">here<\/a>, but the general gist is as follows: <br><br>In the past, almost all embryos would be transferred (or frozen) three days after successful fertilisation. Today, many clinics prefer to transfer or freeze the embryos five or six days after fertilisation instead (when the embryo is at &#8220;<a href=\"\/zygote-embryo-blastocyst-foetus-ivf\/\">blastocyst<\/a>&#8221; stage). <br><br>One of the justifications given by embryologists is that, by the time the embryo has become a blastocyst, it\u2019s already survived a ton of developmental obstacles and is therefore more likely to survive the journey from the doctor\u2019s petri dish to your uterus. (It\u2019s also more likely to survive the freeze-thaw process if it\u2019s being frozen.)<br><br>BUT some embryologists have noted that it\u2019s possible that an embryo&nbsp;<em>wouldn\u2019t&nbsp;<\/em>survive to Day 5 in the petri dish but&nbsp;<em>could&nbsp;<\/em>survive in the uterus if transferred at Day 3.<br><br>If your own treatment failed for this reason (that is, because your embryos struggled to survive beyond Day 3 in the petri dish), ask your doctor about transferring a Day 3 embryo next time. <a href=\"https:\/\/theduff.co.uk\/day-3-vs-day-5-embryos\/\">This article<\/a> covers the topic in much more detail. <\/li><li>Did IVF fail because you didn't eat enough pomegranate or pineapple? Would you have been more successful if you'd bulk-bought CoQ10 or DHEA (likely against your doctor's wishes)? Should you have had more full-fat dairy? Perhaps Brazil nuts? Cut down on coffee? The answer is likely a big fat <a href=\"https:\/\/theduff.co.uk\/ivf-food-pomegranate-pineapple-chips-coq10-dhea-acupuncture\/\">NO<\/a> \u2013 so please stop beating yourself up about it. <\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Reason 3: the embryo had been frozen, and it didn't survive the thawing process<\/strong><\/h3>\n\n\n\n<p>This is one potential risk of embryo freezing, although it's becoming far less common thanks to developments in technology. <a href=\"\/fresh-embryo-transfer-vs-frozen-ivf-uk\/\">Read more about embryo freezing here<\/a>. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Why does IVF fail after embryo transfer?<\/strong><\/h2>\n\n\n\n<p>&#8220;BAD LUCK&#8221; reminder alert!! &#8220;Natural conceptions&#8221; often involve an embryo that fails to implant or miscarries.<\/p>\n\n\n\n<p>As for other reasons&#8230; <\/p>\n\n\n\n<ul><li>I know I'm sounding like a broken record but&#8230; unfortunately, age is again an important reason why IVF fails after embryo transfer. <a href=\"\/egg-quality-quantity-ovarian-reserve\/\">The older you are<\/a>, the more &#8220;poor quality&#8221; eggs you'll have in your batch. <br><br>Poor-quality eggs are often caused by &#8220;chromosomal numerical abnormalities&#8221; (see above), and they don't just struggle to fertilise: they're also more likely to fail to develop into embryos. Even if they<em> <\/em>develop into embryos, they're more likely to fail to implant and\/or develop into a foetus. <a href=\"\/chromosomal-abnormalities-aneuploidy-ivf\/\">Here's more information about numerical abnormalities<\/a>. <br><br>If you're over the age of 37, I know this isn't exactly the most reassuring article you've ever read.<\/li><li>And \u2013 again (sorry for all the repetition) \u2013 poor-quality embryos can result from poor-quality sperm too. (<a href=\"\/sperm-collection-ivf\/\">More info here<\/a>.) Your partner should have already been checked out before IVF, but you can always ask for another test to make sure. <br><br>If it turns out that sperm is causing fertilisation problems, your doctors may recommend ICSI next time (if IVF didn't work this time for sperm-related reasons). <\/li><li>Also again (sorry sorry), younger women can also suffer from a disproportionate number of poor-quality eggs. While age is the most important determinant, egg quality is also affected by smoking, drug use, endometriosis, ovarian cysts, obesity, some immunological disorders, radiation therapy and chemotherapy.<\/li><li>And again&#8230; you or your partner might be a carrier of a different kind of chromosomal abnormality called a &#8220;structural abnormality&#8221;, which is something you can be tested for. <a href=\"https:\/\/theduff.co.uk\/chromosomal-abnormalities-aneuploidy-ivf\/\">Find out about structural abnormalities here<\/a>. <\/li><li>Remember the discussion above about Day 3 vs Day 5 embryos? I mentioned how it's possible that an embryo <em>wouldn't<\/em> survive to Day 5 in the petri dish but <em>could<\/em> survive in the uterus if transferred at Day 3. <br><br>Shittingly, the opposite might also be the case: if your clinic decided to do a Day 3 transfer but the embryo didn't implant, it <em>might <\/em>have been better to let the embryo develop to Day 5. The rationale is that Day 5 is a more natural time for the embryo to be in the uterus. (In a \u201cnatural\u201d pregnancy, the embryo would still be travelling down the fallopian tube at Day 3 \u2013 and would reach the uterus around Day 5.)<br><br>This is a tricky one to get right, and it also depends on the number of embryos you have: clinics might be reluctant to wait until Day 5 if you don't have many embryos, as there's a risk none of them will make it to Day 5. <br><br>If IVF failed after a Day 3 transfer, ask your doctors if they think a Day 5 transfer might be worth considering next time. <\/li><li>There might be an issue with your uterus, which prevents the embryo from implanting successfully. <br><br>You should have had pre-IVF investigations to make sure your uterus is in tip-top condition, but you could ask your doctors if further investigations could be considered. (You can read more about the investigations under &#8220;Pre-IVF step 4&#8221; <a href=\"\/ivf-process-start-to-finish\/\">here<\/a>.) <\/li><li>One opinion is that your embryo might \u2013 for various reasons \u2013 struggle to &#8220;hatch&#8221; when inside the uterus. Successful hatching is necessary for successful implantation. <br><br>Some clinics, therefore, believe that &#8220;assisted hatching&#8221; is a worthwhile technique for some embryos. It's only offered privately, and it's most definitely not endorsed by everyone. <a href=\"\/ivf-food-pomegranate-pineapple-chips-coq10-dhea-acupuncture\/#hatching\">Read more about assisted hatching here<\/a>. <\/li><li><strong>Did IVF fail because you didn't eat enough pomegranate or pineapple? <\/strong>Would you have been more successful if you'd bulk-bought CoQ10 or DHEA (likely against your doctor's wishes)? Should you have gorged on full-fat dairy? Perhaps Brazil nuts? Cut down on coffee? <br><br><strong>Perhaps you ought to have done two days of bed rest after embryo transfer, or stopped exercising?<\/strong> Were those baths too hot? Were you silly for scoffing about acupuncture?<br><br><strong>The answer is likely a big fat <a href=\"https:\/\/theduff.co.uk\/ivf-food-pomegranate-pineapple-chips-coq10-dhea-acupuncture\/\">NO<\/a>. <\/strong>Enough already with blaming yourself! Your actions had no impact on the outcome of your treatment, and you're punishing yourself for nothing. <\/li><\/ul>\n\n\n<style>.elementor-536 .elementor-element.elementor-element-3a6436ac{padding:4% 22% 8% 22%;z-index:2;}.elementor-536 .elementor-element.elementor-element-17d4eb46:not(.elementor-motion-effects-element-type-background) > .elementor-widget-wrap, .elementor-536 .elementor-element.elementor-element-17d4eb46 > .elementor-widget-wrap > .elementor-motion-effects-container > .elementor-motion-effects-layer{background-color:#C0E4E5;}.elementor-536 .elementor-element.elementor-element-17d4eb46 > .elementor-element-populated{transition:background 0.3s, border 0.3s, border-radius 0.3s, box-shadow 0.3s;margin:0% 14% 0% 14%;--e-column-margin-right:14%;--e-column-margin-left:14%;padding:2% 1% 4% 1%;}.elementor-536 .elementor-element.elementor-element-17d4eb46 > .elementor-element-populated > .elementor-background-overlay{transition:background 0.3s, border-radius 0.3s, opacity 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0% 0%;--e-column-margin-right:0%;--e-column-margin-left:0%;padding:8% 6% 12% 6%;}.elementor-536 .elementor-element.elementor-element-576153c1{text-align:center;}.elementor-536 .elementor-element.elementor-element-576153c1 img{width:20%;}.elementor-536 .elementor-element.elementor-element-574ef11f{text-align:left;}.elementor-536 .elementor-element.elementor-element-574ef11f .elementor-heading-title{font-size:1.1em;}.elementor-536 .elementor-element.elementor-element-574ef11f > .elementor-widget-container{margin:4% 0% 6% 0%;}.elementor-536 .elementor-element.elementor-element-3d61ba35 .elementor-post__title, .elementor-536 .elementor-element.elementor-element-3d61ba35 .elementor-post__title a{font-size:1em;}}@media(min-width:768px){.elementor-536 .elementor-element.elementor-element-ef00547{width:13%;}.elementor-536 .elementor-element.elementor-element-19a555d6{width:87.031%;}}@media(max-width:1024px) and (min-width:768px){.elementor-536 .elementor-element.elementor-element-ef00547{width:100%;}.elementor-536 .elementor-element.elementor-element-19a555d6{width:100%;}}<\/style>\t\t<div data-elementor-type=\"section\" data-elementor-id=\"536\" class=\"elementor elementor-536\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3a6436ac elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a6436ac\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-17d4eb46\" data-id=\"17d4eb46\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-40f8e482 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"40f8e482\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-ef00547\" data-id=\"ef00547\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-576153c1 elementor-widget elementor-widget-image\" data-id=\"576153c1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"94\" height=\"142\" src=\"https:\/\/theduff.co.uk\/wp-content\/uploads\/2020\/02\/Group-1294@2x.png\" class=\"attachment-large size-large wp-image-493\" alt=\"Lighbulb illustration\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-19a555d6\" data-id=\"19a555d6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-574ef11f elementor-widget elementor-widget-heading\" data-id=\"574ef11f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">You might also like to read&#8230;<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d61ba35 elementor-grid-1 elementor-posts--thumbnail-none elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-widget elementor-widget-posts\" data-id=\"3d61ba35\" data-element_type=\"widget\" data-settings=\"{&quot;classic_columns&quot;:&quot;1&quot;,&quot;classic_row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:12,&quot;sizes&quot;:[]},&quot;classic_columns_tablet&quot;:&quot;1&quot;,&quot;classic_columns_mobile&quot;:&quot;1&quot;,&quot;classic_row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;classic_row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"posts.classic\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-posts-container elementor-posts elementor-posts--skin-classic elementor-grid\">\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-1420 post type-post status-publish format-standard has-post-thumbnail hentry category-private-treatment-and-nhs-treatment\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<p class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/theduff.co.uk\/best-ivf-fertility-clinics-private-uk\/\" >\n\t\t\t\t<strong>The top-rated fertility clinics<\/strong> in the UK <br>(2021)<\/br>\t\t\t<\/a>\n\t\t<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-2260 post type-post status-publish format-standard has-post-thumbnail hentry category-uncategorized\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<p class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/theduff.co.uk\/feeling-lonely-infertility-1\/\" >\n\t\t\t\t<strong>How to cope with loneliness<\/strong> when you want a baby\t\t\t<\/a>\n\t\t<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-2211 post type-post status-publish format-standard has-post-thumbnail hentry category-coping\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<p class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/theduff.co.uk\/feeling-lonely-infertility\/\" >\n\t\t\t\t<strong>How to cope with loneliness<\/strong> when you want a baby\t\t\t<\/a>\n\t\t<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-2229 post type-post status-publish format-standard has-post-thumbnail hentry category-coping\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<p class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/theduff.co.uk\/two-week-wait-cope\/\" >\n\t\t\t\t<strong>How to cope with the two-week wait<\/strong> after IVF\t\t\t<\/a>\n\t\t<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\n\n\n<h2 class=\"wp-block-heading\"><strong>A brief word about &#8220;next time&#8221;&#8230;<\/strong><\/h2>\n\n\n\n<p>On a few occasions in this article, I've said something along the lines of, &#8220;Next time you do IVF, ask your doctor to consider&#8230;&#8221;. <\/p>\n\n\n\n<p>But I know that many readers won't get a &#8220;next time&#8221;. If that's you and you're reading this, I really hope that your biggest takeaways are the following: <\/p>\n\n\n\n<ol><li>SO much of this is down to luck. <\/li><li>If it's not down to luck, age is a big determinant \u2013 and there's nothing you can do about your age. <\/li><li>It's not your fault. <\/li><\/ol>\n\n\n\n<p>Even if you had another shot at IVF and you did things differently, it doesn't mean you'd be successful. Heck: you could do everything exactly the same and have an entirely different outcome. <\/p>\n\n\n\n<p>So please, please don't blame yourself. 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.elementor-heading-title{font-size:2em;line-height:1.4em;}.elementor-291 .elementor-element.elementor-element-1ed2b9df > .elementor-widget-container{margin:6% 0% 2% 0%;padding:0px 0px 0px 0px;}.elementor-291 .elementor-element.elementor-element-39ffc0a2{font-size:1em;}.elementor-291 .elementor-element.elementor-element-68569f9a .elementor-field-group .elementor-field, .elementor-291 .elementor-element.elementor-element-68569f9a .elementor-field-subgroup label{font-size:1em;}.elementor-291 .elementor-element.elementor-element-68569f9a .elementor-button{font-size:0.8em;letter-spacing:0.2px;border-width:0px 60px 0px 60px;}.elementor-291 .elementor-element.elementor-element-68569f9a > .elementor-widget-container{margin:-4% 0% 10% 0%;padding:0px 0px 0px 0px;}.elementor-291 .elementor-element.elementor-element-4e68b04a{font-size:1em;}}\/* Start custom CSS for button, class: .elementor-element-144e6175 *\/#fdg {\n    color: #FFFFFF;\n}\n#fdg:hover {\n    color: #FFFFFF;\n}\/* End custom CSS *\/<\/style>\t\t<div data-elementor-type=\"section\" data-elementor-id=\"291\" class=\"elementor elementor-291\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c84a175 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c84a175\" data-element_type=\"section\" id=\"Mailing-list-sign-up-box\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-554afbfb\" data-id=\"554afbfb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-21014cc2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"21014cc2\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-7c412ba7\" data-id=\"7c412ba7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-144e6175 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"144e6175\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\" id=\"fdg\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">FREE DOWNLOAD<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ed2b9df elementor-widget elementor-widget-heading\" data-id=\"1ed2b9df\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Questions to ask your doctor at every stage of IVF treatment: free downloadable guide<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39ffc0a2 elementor-widget elementor-widget-text-editor\" data-id=\"39ffc0a2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>IVF isn\u2019t just overwhelming<\/strong>; it can also be a mind-boggling and sometimes terrifying experience because there\u2019s so much to learn and so many rules to follow.<\/p><p>Problem is, doctors are busy \u2013 and they often don\u2019t have the time to anticipate your concerns and provide all the information you might need.<\/p><p>This downloadable guide contains questions that will help you understand the process better, get the answers you deserve, and feel more in control of the situation (and your rights as a patient).<\/p><p><strong>Enter your email address to receive it right away.<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-68569f9a elementor-mobile-button-align-center elementor-tablet-button-align-stretch elementor-button-align-stretch elementor-widget elementor-widget-form\" data-id=\"68569f9a\" data-element_type=\"widget\" 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